Prostanoid Metabolites and Colorectal Adenoma Occurrence
Aspirin has been shown to protect against colorectal neoplasms; however, the optimal chemopreventive dose and underlying mechanisms are unclear. We aimed to study the relationship between prostanoid...
View ArticleFish Oil and Butyrate Effects on Colon Cell Kinetics
We have shown that dietary fish oil is protective against experimentally induced colon cancer, and the protective effect is enhanced by coadministration of pectin. However, the underlying mechanisms...
View ArticleMAPRE1 for Early Detection of Colorectal Cancer
Blood-based biomarkers for early detection of colorectal cancer could complement current approaches to colorectal cancer screening. We previously identified the APC-binding protein MAPRE1 as a...
View ArticleIsoflavone Bioavailability of Soy Breads in Prostate Cancer
Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted...
View ArticlePAK1 Deletion Impairs Intestinal Tumorigenesis
p21-activated kinase 1 (PAK1) is a serine/threonine kinase that is overexpressed in colorectal cancer. PAK1 is a target of mesalamine [5-aminosylicylic acid (5-ASA)], a common drug for the treatment of...
View ArticlePhase I Trial of Poly E in Barrett's Esophagus
This study was conducted to determine the safety and efficacy of the green tea–derived Polyphenon E (Poly E) in patients with Barrett's Esophagus (BE). Subjects were randomized to a 6-month, twice...
View ArticleLeptin, Adiponectin, and Human Mammary Stem Cells
Multiple mechanisms are likely to account for the link between obesity and increased risk of postmenopausal breast cancer. Two adipokines, leptin and adiponectin, are of particular interest due to...
View ArticleAcolbifene for Breast Cancer Prevention
The purpose of this study was to assess the feasibility of using the selective estrogen receptor modulator (SERM) acolbifene as a breast cancer prevention agent in premenopausal women. To do so, we...
View ArticleNSAID Use and Risk of Liver Cancer
Chronic inflammation plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), the two most common types of liver cancer. A number of prior...
View ArticleAdiponectin and Survival in Colorectal Cancer Patients
Circulating adiponectin is inversely related to the risk of colorectal cancer. However, its influence on colorectal cancer survival is unclear. We conducted a prospective study to evaluate the...
View ArticlePAX2 in Ovarian Cancer Etiology and Progression
PAX2 is an essential transcription factor for development. Aberrant PAX2 expression in adult tissues is associated with carcinogenesis and experimental evidence shows that PAX2 generally exhibits...
View ArticleSulforaphane and Chemopreventive Activity
Epidemiologic studies suggest a protective effect of cruciferous vegetables on breast cancer. Sulforaphane (SFN), an active food component derived from crucifers, has been shown to be effective in...
View ArticleRexinoids and Chemoprevention of Lung Carcinogenesis
LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that...
View ArticleTransforming Cancer Prevention
We have entered a transformative period in cancer prevention (including early detection). Remarkable progress in precision medicine and immune-oncology, driven by extraordinary recent advances in...
View ArticlePersistence of Bronchial Dysplasia and Lung Cancer Risk
Bronchial dysplasia (BD), a presumed precursor of pulmonary squamous cell carcinoma (SCC), rarely progresses to invasive cancer. A high-risk cohort at the University of Colorado provided an opportunity...
View ArticleSedentary Behavior and Lower BRCA1 Expression
BRCA1 mutation carriers face a high lifetime risk of developing breast cancer. Physical activity induces broad transcriptional changes, and multiple studies have documented its beneficial effects...
View ArticleInflammatory Markers and Advanced Colorectal Adenoma
Evidence remains inconclusive about the association of systemic inflammatory markers with colorectal neoplasia. We investigated whether circulating inflammatory markers were associated with risk of...
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